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두 약물의 주요 차이점은 작용 지속 기한과 응답 빠르기에 있다. 비아그라는 섭취 후 약 50분에서 3시간 이내에 효능이 나타나며, 효과 지속 시간은 약 4~9시간입니다. 반면에 시알리스는 섭취 후 약 18분에서 50분 이내에 효과가 나타나며, 효과 지속 시간은 약 34시간에 이릅니다. 이처럼 특성 덕분에 시알리스는 "휴일 약"으로 불리기도 합니다.